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Composition : Etoposide

Manufacturer : Cadila

Indication : Ovarian cancer, Leukemia, Lymphoma, Testicular cancer, and Prostate cancer.

Packaging : Vial

Dosage Form : Injection



Overview of Posid 

Posid is a formulation of a podophyllotoxin derivative namely Etoposide. It is a prescription medicine used in combination with other chemotherapeutic agents for the treatment of patients diagnosed with Kaposi’s Sarcoma, Ewing’s Sarcoma, small cell Lung Cancer, Blood Cancer (Lymphoma and Leukemia), Lymphatic Cancer, and Testicular Cancer. This chemotherapy regimen is also used in the treatment of an uncommon hematologic disorder known as Hemophagocytic Lymphohistiocytosis. Posid is available in the form of an injection in the fixed strength of 100 mg by Cadila Pharmaceuticals Ltd. It should be administered under a clinical setup by a nurse. 

The active ingredient of Posid injection is Etoposide. The regimen belongs to the category of medications known as topoisomerase inhibitors that exhibit antitumor activity.  Posid injection works by inhibiting DNA synthesis by creating a complex with topoisomerase II and DNA. This leads to the induction of breaks in double-stranded DNA while hindering repair by topoisomerase II binding. Further, it causes cell death due to the prevention of entry inside the mitotic phase of cell division. This also slows the growth of cancerous cells by eventually killing them. 


Drugs show interactions with other elements differently from one patient to the other. Here are a few of the possible interactions concerning Posid Injection. 

Drug Interactions: Phenobarbital, Live attenuated vaccines, and related products, Adalimumab, Phenytoin, Carboplatin, and Clozapine are the medications that can show clinically significant interactions with the ingredients of Posid injection including Etoposide. Due to such interactions during Posid therapy, you may experience adverse events. Tell your doctor beforehand if you administer any of these medicines so that the dose adjustments can be initiated, if necessary. 

Disease Interactions: Patients having severe infections or suffering from Myelosuppression should make their doctor aware of the same. This is because such diseases can show clinically significant interactions with the ingredients of Posid injection including Etoposide. Due to such interactions during Posid therapy, you may experience adverse events. Learn the necessity of dose adjustments concerning such interactions. 

Food Interactions: Grapefruit and its products are responsible for the inhibition of CYP3A4 metabolism. This can lead to a significant rise in serum levels of Etoposide. St. John’s Wort is a herb that is thought to interact with the ingredients of Posid injection. Food items containing such components should be avoided. Alcohol consumption should be ideally limited during Posid therapy since it can also show severe interactions with Etoposide.

Q1- What is Posid (Etoposide)?

A- Posid (Etoposide) is an anti-cancer medication. It is used in the treatment of various types of cancers such as cancers of the lung and testicles.

Q2- What are the storage conditions for Posid?

A- Store Posid at room temperature (10-30°C). Protect from direct heat, light, and moisture.

Q3- What are the common side effects of Posid?

A- Some of the common side effects of Posid injection are vomiting, nausea, diarrhea, skin rash, itching, hair loss, low blood platelets, anemia, etc. Contact your healthcare provider in case side effects (these or other) occur or last long.

Q4- What is the composition and strength of Posid?

A- The active ingredient of Posid injection is Etoposide. It belongs to the topoisomerase inhibitor family of medication. Posid injection is available in the strength of 100 mg.

Q5- How does Posid injection work?

A- Posid injection comprises Etoposide. It belongs to the topoisomerase inhibitor family of medication. It works by damaging the DNA. It is given intravenously.

Q6- How should I take this medicine?

A- Posid injection is given by the medical practitioner. It should not be self-administered. It is advised to not skip a scheduled dose of Posid.

Q7- What should be done in cases of overdose and missed dose?

A- In case you miss a dose, make sure to contact your healthcare provider for further guidance. This medicine is given by a healthcare professional, therefore chances of overdose are very less. However, if symptoms of overdose occur, seek medical attention immediately.

Q8- What are the warnings and precautionary steps?

Warning– Discuss the following points with a medical practitioner before taking Posid injection (if applicable):

  • Contraception
  • Liver function
  • Pregnancy
  • Breastfeeding 
  • Alcohol
  • Diet plan

Precautions– Make sure to avoid:

  • Activities that increase the risk of bleeding
  • Drinking alcohol while consuming this medicine
  • Driving or operating heavy machinery

Q9- Is it safe to take Posid during pregnancy or breastfeeding?

A- During pregnancy or breastfeeding, make sure to consult a medical practitioner beforehand. Also, discuss the potential risks and benefits associated with the consumption of this medicine. 

Q10- Is it safe to drive after taking Posid?

A- After taking Posid injection, you may feel drowsy or unwell. If such side effects occur, avoid driving or operating heavy machines.

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