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Composition : Relugolix

Manufacturer : Myovant

Indication : Prostate Cancer

Packaging : Bottle

Dosage Form : Tablet



Overview of Orgovyx

Orgovyx is a formulation of an oral GnRH receptor antagonist namely Relugolix. It is also known as a gonadotropin-releasing hormone antagonist used for androgen deprivation therapy in the treatment of male patients diagnosed with advanced Prostate Cancer. Unlike other Gonadotropin-releasing hormone modulators, Orgovyx is an orally active, non-peptide, small molecule compound. Orgovyx (Relugolix) is available in the form of oral tablets in the fixed strength of 120mg by Myovant Sciences. It should be ideally administered once daily in the dose prescribed by the physician. 

The active ingredient of Orgovyx tablets is Relugolix. Its inactive ingredients are hydroxypropyl cellulose, mannitol, hypromellose, carnauba wax, ferric oxide red, titanium dioxide, magnesium stearate, and sodium starch glycolate. Relugolix works by suppressing the levels of sex steroids in both males and females to the postmenopausal or castrate range. The drug binds to the GnRH receptor in a competitive manner. It blocks the action of the GnRH receptor in the anterior pituitary gland by the inhibition of LH secretion and release. This mechanism of the drug further hinders the release of testosterone in the testes from Leydig cells. 


The following are some of the interactions concerning the administration of Orgovyx (Relugolix) tablets. 

Drug Interactions: Medications containing Acetaminophen, Albuterol, Amiodarone, Azithromycin, Ticagrelor, Famotidine, and/or Tramadol as active ingredients may cause severe interactions with the compounds present in Orgovyx tablets including Relugolix. If you are already prescribed any of these drugs, it becomes necessary to inform the physician about this medical condition prior to the administration of the first dose. You might need dose adjustments concerning Orgovyx (Relugolix) and these medications. 

Disease Interactions: QT Prolongation is the only disease that is known to interact with the compounds present in Orgovyx tablets including Relugolix. If you are diagnosed with QT Prolongation or are suffering from any such related symptoms, it becomes necessary to inform the physician about this medical condition prior to the administration of the first dose. You might need dose adjustments concerning Orgovyx (Relugolix). 

Food Interactions: Orgovyx (Relugolix) tablets can be administered with or with food. Food does not stimulate any clinically significant differences in the pharmacokinetics of Relugolix. Alcohol consumption during Orgovyx therapy, however, should be limited since Relugolix can interact with alcohol severely. 

Q1- What is Orgovyx (Relugolix)?

A- Orgovyx (Relugolix) tablet is an anticancer medicine. It is used in the treatment of adult patients with Advanced Prostate Cancer. 

Q2- What are the storage conditions for Orgovyx?

A- Store Orgovyx (Relugolix) tablets at room temperature. Don’t store above 30°C (86°F). Keep it away from the reach of children and pets.

Q3- What are the common side effects of Orgovyx?

A- Some of the common side effects of Orgovyx (Relugolix) tablets are chest pain, constipation, fainting, dizziness, muscle pain, joint pain, hot flushes, etc. There can be other side effects also. Therefore, make sure to contact a medical practitioner if side effects occur or last longer than usual.

Q4- What is the composition and strength of Orgovyx?

A- The active ingredient of Orgovyx is Relugolix. It is available in the strength of 120 mg in the form of tablets for oral administration.

Q5- What are self-care tips?

A- Follow your healthcare provider’s instructions regarding restrictions on food and others.

Q6- How should I take this medicine?

A- Take Orgovyx (Relugolix) tablet exactly in the same dose and duration as prescribed by your healthcare provider. Do not skip a dose. Do not increase or decrease the dose strength unless your doctor tells you.

Q7- What should be done in cases of overdose and missed dose?

A- In case you miss a dose, make sure to take the dose as soon as you remember. However, skip the missed dose if it is already the time for your next scheduled dose. Also, call your doctor. In case of overdose, seek emergency medical attention. 

Q8- What are the warnings and precautionary steps?

A- Before the consumption of Orgovyx (Relugolix) tablet, it is advised to contact a healthcare professional regarding:

  • Your medical history 
  • Your medical condition
  • Any scheduled vaccine
  • Any allergy you have or ever had
  • Any disease you have or ever had
  • Medicines/supplements you already take

Q9- Is it safe to take Orgovyx (Relugolix) tablets during pregnancy or breastfeeding?

A-Taking Orgovyx (Relugolix) tablet during pregnancy or breastfeeding might not be safe. Consult your healthcare provider.

Q10- Is it safe to drive after taking Orgovyx (Relugolix) tablet?

A- After taking Orgovyx (Relugolix) tablet, you may feel dizzy or unwell. Make sure to avoid driving if such side effects occur.

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