Bendamustine is an active agent present in this medication termed Leuben and it belongs to a family of antineoplastics known as alkylating agents. Leuben is available in the form of injection with a strength of 100mg and it is prescribed for the treatment of NHL (Non-Hodgkin’s Lymphoma). This injection works by damaging the DNA and RNA of cancer cells (genetic material) and it also helps in preventing the spread of cancer cells. Leuben injection is administered to the patients through an IV (intravenous) line under the supervision of a qualified and trained healthcare team.
Bendamustine is a bifunctional mechlorethamine derivative that can covalently connect to other compounds by creating electrophilic alkyl groups. Bendamustine acts as an alkylating agent, causing intra- and interstrand cross links between DNA bases, which leads to cell death.
Using Leuben (Bendamustine) with other non-prescribed medications such as – vitamins, herbal supplements, or any other medicinal product, increases the risk of adverse reactions. Do not use such medication while receiving therapy with Leuben injection.
Medicine interactions:- adalimumab, certolizumab, fingolimod, golimumab, leflunomide, ponesimod, teriflunomide, etc are the drugs that may increase or decrease the serum concentration and also increases the risk of severe infections. Avoid the use of Leuben (Bendamustine) injection with any of the medications that may interact.
Disease interactions:- hepatic impairment, myelosuppression, and renal impairment are some of the diseases that may interact moderately or majorly with the anti-cancer medication Leuben (Bendamustine), in order to avoid these interactions extreme caution is recommended for patients.
Food interactions:- Avoid the use of caffeine products because it may increase the blood levels of bendamustine and it may cause severe side effects like -anemia, bleeding problems, or infections, and it can also affect your bone marrow function, resulting in low numbers of blood cells.
Alcohol interactions:- consuming alcohol while receiving treatment with Leuben (Bendamustine) injection may increase the risk of dizziness, lightheadedness, and change in vision in some patients. It is better to avoid the consumption of alcohol and other alcoholic beverages. Consult with your healthcare professional or medical practitioner before consuming it.
Q1- What is Leuben (Bendamustine) used for?
A- Leuben (Bendamustine) is used in the treatment of cancer of the lymphatic system such as Non-Hodgkin’s Lymphoma (NHL). It belongs to a group of cancer-fighting medications known as alkylating agents. It may also be used in the treatment of other types of cancer such as chronic lymphocytic leukemia (CLL), multiple myeloma as prescribed by your doctor.
Q2- How should I take this medicine?
A- This medicine is given as an injection into the vein. Your healthcare provider will give you this medicine. Do not try to self administer.
Q3- How does Leuben (Bendamustine) work?
A- Leuben comprises Bendamustine. It is in the alkylating agents family of medication and interferes with the function of DNA and RNA.
Q4- In what composition is it available?
A- The active ingredient of Leuben is Bendamustine. This medicine is available in the form of an injection in the strength of 100 mg.
Q5- What are the possible side effects of Leuben (Bendamustine)?
A- Some of the possible side effects of Leuben (Bendamustine) are anemia, headache, nausea, fever, dizziness, weight loss, loss of appetite, bleeding gums, blood in urine, etc. There may be other side effects also. Make sure to contact your healthcare professional to get proper guidance and avoid further complications.
Q6- How should Leuben be stored?
A- Store Leuben (Bendamustine) at room temperature (10-30°C). Keep it away from children and pets.
Q7- Can I take Leuben (Bendamustine) during pregnancy or breastfeeding?
A- Leuben (Bendamustine) injection should be administered during pregnancy or breastfeeding only after discussing the potential risks and benefits with the medical practitioner.
Q8- Name some alternate brands of Leuben (Bendamustine) injection?
A- Following are the substitutes for Leuben (Bendamustine) injection:
- MyMust Injection
- Ribomustin Injection
- Bedamax 100 Injection
Q9- What are the warnings and necessary precautions?
A- Leuben (Bendamustine) injection should be administered with caution in patients who:
- Are pregnant or plan to become pregnant
- Are breastfeeding or plan to breastfeed
- Who already have depression disorders
- Who have cardiac disease and thyroid disorders
Q10- What are self-care tips?
A- Leuben (Bendamustine) affects the immune system. It may increase the risk of getting infections more easily. Therefore, it is advised to avoid contact with other people who have infections.