Overview of Darzalex
Darzalex is an established formulation of a CD38-directed cytolytic antibody namely Daratumumab. It is a prescription used in the treatment of multiple myeloma, a type of Blood Cancer. Specifically, it is a component of combination therapy in:
- Newly diagnosed patients with relapsed or refractory multiple myeloma who are not eligible for autologous stem cell transplant and have received at least one prior therapy.
- Newly diagnosed patients who are eligible for autologous stem cell transplant.
- Patients with multiple myeloma who have received at least two prior treatments including a proteasome inhibitor and lenalidomide.
Other than this, Darzalex is used as a monotherapy in patients with multiple myeloma who have received at least three prior treatments. It is available in the form of an injection (single-dose vial) in the strength of 20 mg/ml for intravenous use only. Darzalex injection is administered by a medical professional.
The active ingredient of Darzalex injection is Daratumumab. Its inactive ingredients are glacial acetic acid, water, polysorbate 20, sodium chloride, sodium acetate trihydrate, and mannitol. Darzalex injection has a long duration of action. It is given every 2-4 weeks. It may be prescribed in combination with medications like Dexamethasone, Lenalidomide, Bortezomib, Prednisone, and Thalidomide.
The following are a few of the clinically relevant interactions concerning Darzalex (Daratumumab) injection.
Drug Interactions: Etanercept, Certolizumab, Clozapine, Adalimumab, and Infliximab are the known medications that may show significant interactions with the components present in Darzalex injection including Daratumumab. There may be other drug interactions also. Therefore, it is always recommended to inform the healthcare team about the regimens you already prescribed before starting any new therapy.
Disease Interactions: Cytopenia and infusion reactions are the known conditions that may show significant interactions with the components present in Darzalex injection including Daratumumab. There may be other disease interactions also. Therefore, it is always recommended to inform the healthcare team about the diseases you are already diagnosed with before starting any new therapy.
Alcohol Interactions: Alcohol consumption should be limited or avoided during Darzalex (Daratumumab) therapy in order to prevent complications associated with their interactions. No other significant food interactions are known. Ask your medical team for a proper diet plan during Darzalex therapy.
Q1- What is Darzalex (Daratumumab)?
A- Darzalex (Daratumumab) injection is an anti-cancer medication. It is used in the treatment of Multiple Myeloma. It is a monoclonal antibody, which is directed against CD38, a molecule present on myeloma cells.
Q2- What are the storage conditions for Darzalex (Daratumumab)?
A- Store Darzalex (Daratumumab) injection in a refrigerator at 2°C to 8°C (36°F to 46°F). Protect from light, heat, and moisture. Keep it away from the reach of children and pets.
Q3- What are the common side effects of Darzalex (Daratumumab)?
A- Some of the common effects of Darzalex (Daratumumab) injection are body ache, weakness, insomnia, fever, chills, vomiting, nausea, fatigue, stomach ache, etc. There can be other side effects also. Therefore, make sure to contact a doctor if side effects occur or last longer than usual.
Q4- What is the composition and strength of Darzalex?
A- The active ingredient of Darzalex is Daratumumab. It is available in the form of an injection in the strengths of 100 mg/5 mL and 400 mg/20 mL.
Q5- What are self-care tips?
A- Eat a healthy and nutritional diet, advised by a professional healthcare provider. Avoid the consumption of alcohol.
Q6- How should I take this medicine?
A- Your healthcare provider will give you this medicine. Do not self administer.
Q7- What should be done in cases of overdose and missed dose?
Overdose: In case of overdose, seek emergency medical attention to get needed support.
Missed dose: In case you miss a dose, take the dose as soon as you remember if it is not already the time for your next scheduled dose. Also, be sure to call your healthcare provider for the same. Do not double the dose to catch up with the missed dose.
Q8- What are the warnings and precautionary steps?
A- Before the consumption of this medicine, it is advised to contact a healthcare professional regarding:
- Your medical history
- Your medical condition
- Any scheduled vaccine
- Any allergy you have or ever had
- Any disease you have or ever had
- Medicines/supplements you already take
Q9- Is it safe to take Darzalex (Daratumumab) injection during pregnancy or breastfeeding?
A- Taking Darzalex (Daratumumab) injection during pregnancy or breastfeeding might not be safe. Consult your healthcare provider.
Q10- Is it safe to drive after taking Darzalex (Daratumumab) injection?
A- After taking Darzalex (Daratumumab) injection, you may feel dizzy or unwell. Make sure to avoid driving if such side effects occur.